The ethical and research review committees of both the ICDDR,B and Karolinska Institute approved the study. With few exceptions, the studies did not quantitatively evaluate stool output. The factors for increased proportion of rotavirus-infected subjects might be related to the stringent enrollment criteria used in this study, which favored severe diarrhea and, hence, perhaps rotavirus infections. The largest sample size of 102 patients in each group was therefore chosen as a desired sample size. It is therefore likely that neither Lactobacillus GG nor ST11 is of clinical benefit in the management of severe rotavirus gastroenteritis that leads to hospitalization in developing countries. The cells of L. paracasei are typically rod shaped, with a size range of 2.0μm to 4.0μm in width, and 0.8 to 1.0μm in length. This work was supported by the Swedish agency for research in developing countries (SAREC), the Karolinska Institute (Stockholm, Sweden), and Nestlé Research Centre (Lausanne, Switzerland). Potency: 5 billion – 100 billion CFU/g The study was conducted between February 2001 and December 2002. Putting It All Together to Understand the Role of Malassezia spp. It is available as white, to cream-colored, free-flowing powder. Get the latest public health information from CDC: https://www.coronavirus.gov. USA.gov. Packaging: 1 kg & 2 kg aluminum foil bags. A new probiotic strain, Lactobacillus paracasei strain ST11 (ST11), which was isolated from stools of a 4-week-old breastfed healthy girl (her name was Stephanie, and it was the 11th colony isolated from her stool, hence the name ST11). In a randomized, double-blind, placebo-controlled clinical trial, 230 male infants and young children, 4 to 24 months of age, presenting with diarrhea of <2 days' duration were admitted to the metabolic research ward of the International Centre for Diarrheal Disease Research, Bangladesh, and fed 1010 colony-forming units of lyophilized ST11 or placebo daily for 5 days. That is, the amounts of ORS and the duration of diarrhea, stool frequency, and time to recovery from illness were similar. Written consent was required from parents or guardians for enrollment of each child in the study. The study was conducted in the metabolic research ward of the ICDDR,B, which has a total of 12 beds. However, the current study demonstrated a much higher rate of rotavirus infections. The organism is nonmotile. The sample size was calculated based on 3 outcome measures: duration of diarrhea, stool volume, and frequency of stool, which were reported earlier to be 74 hours,19 217 g/kg ever 48 hours,20 and 13.75 per d,21 respectively, in acute watery diarrhea. To explore this possibility, we separated the patients into 2 groups: rotavirus-infected patients and non–rotavirus-infected patients. The current trial suggests an effect of ST11 on nonrotavirus diarrhea, but a confirmation of this result with a greater number of children and a better definition of the etiology is clearly warranted. A new probiotic strain, Lactobacillus paracasei strain ST11 (ST11), which was isolated from stools of a 4-week-old breastfed healthy girl (her name was Stephanie, and it was the 11th colony isolated from her stool, hence the name ST11). doi: 10.1371/journal.pone.0225796. Both placebo and lyophilized Lparacasei were packaged in identical sachets. Children were placed on a “cholera cot,” and urine collection bags were applied for separate collections of stool and urine. We thank Dr M.A. In rotavirus-infected children, 30 children (12 in the ST11 group and 18 in the placebo group) had additional pathogens other than vibrios such as Salmonella, Shigella, and Campylobacter, as indicated in Table 1. Source: Healthy Human No adverse events were reported. Phage therapy: an alternative or adjunct to antibiotics? The efficacy of Lactobacillus paracasei NCC 2461 ST11 (ST11) to manage dandruff and to restore a balanced scalp microbiome was assessed. L. paracasei cells often have square ends, and may exist either in single form or in chains. Packaging: 1 kg & 2 kg aluminum foil bags. DOI: https://doi.org/10.1542/peds.2004-2334, ICDDR,B, International Centre for Diarrheal Disease Research, Bangladesh, The Prolongation of Life: Optimistic Studies, The Rational Use of Drugs in the Management of Acute Diarrhoea in Children, A Manual for the Treatment of Diarrhoea for Use by Physicians and Other Senior Health Workers, Cerebral Lymphoma in an Adenosine Deaminase–Deficient Patient With Severe Combined Immunodeficiency Receiving Polyethylene Glycol–Conjugated Adenosine Deaminase, Disparate Clinical Presentation of Neonatal Hemochromatosis in Twins, Infections and Kawasaki Disease: Implications for Coronary Artery Outcome, Follow American Academy of Pediatrics on Instagram, Visit American Academy of Pediatrics on Facebook, Follow American Academy of Pediatrics on Twitter, Follow American Academy of Pediatrics on Youtube, Lactobacillus paracasei Strain ST11 Has No Effect on Rotavirus but Ameliorates the Outcome of Nonrotavirus Diarrhea in Children From Bangladesh. Potency: 400 billion CFU/g 2018 Dec;183(6):893-903. doi: 10.1007/s11046-018-0283-4. Intravenous solutions were used if ORS therapy failed to match ongoing stool losses (unscheduled intravenous therapy) because of either severe vomiting or high rates of purging with reappearance of the signs of dehydration as assessed by a physician using World Health Organization guidelines.18 Unscheduled intravenous fluid was discontinued as soon as dehydration was corrected and administration of ORS was resumed for matching ongoing loss. Packaging: 1 kg & 2 kg aluminum foil bags. Already with the limited analysis we realized that some rotavirus-infected patients showed also a bacterial copathogen. Laboratory studies included determination of serum concentration of sodium, potassium, and chloride, total carbon dioxide, serum specific gravity, total protein, and complete blood count, and stools were tested for Salmonella, Shigella, and Campylobacter. The difference in cumulative ORS intake, cumulative stool output and stool frequency, and resolution of diarrhea was statistically significant despite the relatively small number of non–rotavirus-infected patients in our study. No effect of ST11 treatment on severe rotavirus diarrhea was observed. Changes in the consistency of the stool (loose or watery, stool that can be poured from one container to another; soft stool that conforms to the anatomy of patient's rectum; or formed stool having its own shape) were also monitored and recorded. Despite being backed by statistical significance, the results should therefore be interpreted with caution, because they are based on a small and perhaps selected patient collective. However, this measure alone is not considered optimal. Male infants and young children, aged 4 to 24 months, with a history of acute watery diarrhea (≥4 liquid stools during 24 hours) of <48 hours' duration, hospitalized at the Dhaka Hospital of the International Centre for Diarrheal Disease Research, Bangladesh (ICDDR,B), were included in this study. An imbalanced proportion of the major bacterial and fungal populations colonising the scalp, a skin barrier dysfunction, and hyperseborrhoea are three main etiological factors of dandruff. The master randomization code and 2 sets of code envelopes detailing treatment allocation of a given patient were generated by an independent statistician not involved in the study.
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